04
Amgen · Enbrel

Patient Experience Redesign & UX Research Leadership

Diagnosing a dual-audience architecture failure after a site redesign collapsed engagement metrics, then leading the research commissioning and UX redesign that charted the path back.

UX Audit Site Redesign Dual-Audience Architecture Research Leadership Vendor Evaluation
Amgen · Enbrel · Arnold NYC
An 89% bounce rate meant
the redesign wasn't working.
We rebuilt around the condition, not the interface.
89% bounce rate → condition-first redesign
Challenge
A February 2021 redesign collapsed engagement — bounce rate climbed from 63% to 89% within weeks.
Approach
Commissioned research, diagnosed the real architecture failure, and delivered a 53-page condition-first redesign.
Outcome
A structural fix addressing the root cause, not a surface-level navigation patch.
Problem & insight
UX approach
Decision log
Deliverables
Hindsight
All case studies →
From brief to reframed problem

The brief came in as a navigation and content findability problem. The diagnosis revealed an architectural failure two levels deeper.

Client brief

“The redesigned site is underperforming — users can’t find what they need. Fix the navigation and improve content findability.”

Reframed UX problem

This isn’t a navigation problem — it’s a dual-audience architecture failure. Enbrel.com serves two fundamentally different users: prospective patients deciding whether to start Enbrel, and current patients who need support, financial resources, and adherence tools. The redesign treated them as one. No amount of navigation improvement resolves an architecture that assumes a single user intent.

This reframe changed scope from incremental fixes to a structural solution — driving the dual-path homepage architecture that became the foundation of WEBDEV2.0.

Transferable to

Multi-audience regulated digital experiences. The dual-audience architecture failure pattern applies across any regulated brand serving more than one user intent from a single digital property — pharma DTC/HCP, device manufacturer patient/provider, and payer member/broker experiences all face the same orientation failure when architecture assumes a single user intent.

Key insight

Drop-off was immediate and homepage-driven, not distributed across the site. Bounce rate spiked from 63% to 69% within the first week post-launch and reached 89% within three months. Concentration at the homepage confirmed users were failing to orient at the first interaction — not failing to find specific content after navigating in.

UX approach

I treated this as an architecture problem before a design one — first building the evidentiary case from 14 months of analytics that the metric collapse had a single structural cause, then commissioning an independent Ipsos study to move from hypothesis to client-defensible evidence. The redesign itself was condition-first: “Choose Your Condition” became the primary entry point, separating prospective and current patient paths from the first interaction.

Key design decisions
Decision point Alternatives considered What we chose & why
Homepage architecture — product-first vs. condition-first
Lead with Enbrel brand narrative, letting users self-navigate to condition pages via secondary nav.
Condition-first — data showed homepage drop-off was the primary failure point because users couldn't orient without a condition entry point above the fold.
Dual-path CTA — single vs. split prospective/current patient
Single primary CTA: “Talk to your doctor about Enbrel.” One entry point for both users.
Split dual-path CTAs — “Thinking about ENBREL?” vs. “Already have a prescription?” — since one CTA serving two incompatible needs guaranteed a poor experience for one group every time.
URL strategy — maintain redesigned URLs vs. restore pre-launch
Maintain redesigned URLs with 301 redirects and improved internal linking to rebuild SEO authority over time.
Restored pre-launch URLs for high-traffic pages — SEO authority loss was a material driver of the traffic decline, and redirect chains were compounding an engagement problem with an acquisition problem.
Figure 01 · Homepage redesign Before / after — annotated
Enbrel.com homepage redesign — annotated before/after, Arnold NYC

Homepage index page redesign — before/after comparison with annotated UX rationale. Arnold NYC, August 2021 (R2). Left: current site with the flat, undifferentiated homepage structure and condition-selection buried below the fold. Right: proposed redesign with annotations for navigation restructuring, responsive CTA placement, and condition-first dropdown implementation. Three annotated decisions: content display (removing condition block reduces scroll depth and bounce risk), responsive CTA (add condition-selection above fold), and navigation (horizontal menu collapses to separate-click buttons per mobile UX patterns).

The annotated before/after gave the client a visual argument for scope change — moving the conversation from 'fix the nav' to 'rebuild the architecture.'

Figure 02 · Homepage before & after R8 single-path (left) → R14 condition-first, dual-path (right)

Homepage before/after — R8 (left) vs. R14 (right). Before: generic brand hero (“I’M IN for what’s next”) with no condition-entry point, no patient-path separation, and a generic Paying for ENBREL CTA as the primary above-fold action. After: condition-first architecture with “Thinking about ENBREL?” prospective patient hero, the “Choose Your Condition” dropdown as the primary navigation entry, and a scrolled current-patient path (“Already have a prescription?”) separating the two user intents. The structural shift resolved the dual-audience failure that drove bounce rate from 63% to 89%.

The dual-path hero resolved the single biggest orientation failure: users could identify their path before any brand narrative was introduced.

Figure 03 · Condition navigation Choose Your Condition — open state
Enbrel.com condition-first navigation — open state, mobile wireframe R14

Mobile navigation open state — “Choose Your Condition” as the primary nav entry point, surfacing all six approved indications before any other content. Patients self-sort by condition on the first interaction, routing to condition-specific content rather than a generic product page. The condition-first hierarchy reversed the previous architecture where conditions were buried two levels below the brand narrative.

Condition-first navigation reversed the previous architecture — patients self-sorted by condition on the first interaction rather than navigating through brand content to find it.

Figure 04 · Site architecture Enbrel SiteMap 2.0 — full IA
Enbrel.com SiteMap 2.0 — full information architecture

Enbrel SiteMap 2.0 — full information architecture delivered as part of WEBDEV2.0. HOME node branches into eight top-level sections: SELECT CONDITION (six indications, each with condition-specific sub-pages), IMPORTANT SAFETY INFORMATION, PRESCRIBING INFORMATION, MEDICATION GUIDE, PAYING FOR ENBREL, ENBREL SUPPORTPLUS (the current patient support hub), ESPAÑOL SITE, and HEALTHCARE PROFESSIONALS. Each condition branch carries parallel sub-page structure: condition overview, how Enbrel works, results, patient stories, common side effects, talk to your doctor, and DDO download. Financial support and injection training sections documented to form-field and flow-state level. 53 wireframe pages, R8–R14.

The full sitemap gave the WEBDEV2.0 team a build-ready IA — every page, branch, and sub-section documented to form-field level across 53 pages.

Role
UX diagnosis, research strategy & redesign lead — 53-page wireframe suite across six revisions
Collaboration
Primary UX voice within Arnold NYC — aligning strategy with account leadership internally so recommendations arrived as a unified position; every deliverable was built for Amgen to act on directly.
Deliverables
UX research brief (3 iterations) · Discovery session deck · Vendor evaluation POV · Index page redesign R1, R2 · Full site wireframes (53 pages, R8–R14)
Regulatory context
MLR-reviewed pharma DTC
Industry
Pharmaceutical · Biologic · Patient experience
What would’ve made this stronger

The dual-audience diagnosis was right, and the Ipsos brief gave it defensible weight with the client. Two things worth pushing further: a competitive audit of other pharma DTC sites serving dual audiences, run before the research brief, to give the reframe external reference points the client could evaluate without commissioning a study of their own. And instrumenting the post-launch measurement framework before the redesign went live, not after the collapse became visible in monthly reporting — the Cardinal Path data told the story, but it was telling it six weeks late.