03
Eli Lilly · Verzenio

Experience Architecture & Competitive Intelligence

Designing oncology experience architecture to support informed treatment understanding across complex, multi-pathway disease management — backed by competitive landscape analysis.

Experience Design UX Architecture Competitive Intelligence Oncology Breast Cancer FDA · MLR
Eli Lilly Verzenio
2
Patient journeys from one UX architecture
6
MLR watch items sequenced into review alignment
MLR-approved
EBC and MBC DTC platform delivered
Challenge
Problem reframe
UX approach
Decision log
Research → insight
Deliverables
Hindsight
The challenge

Verzenio serves patients across meaningfully different disease stages — early and metastatic breast cancer — each with distinct treatment goals, support needs, and emotional contexts. A single UX model couldn't serve both without creating confusion or clinical risk.

The experience design gap wasn't informational — it was architectural. Content existed but the UX structure didn't reflect where different patients actually were in their journey. A single undifferentiated model created confusion and clinical risk for EBC patients who didn't yet identify as having a serious disease, and failed MBC patients who needed evidence and context before emotional support.

My role: I led experience design and UX architecture across the Verzenio patient support ecosystem — defining the structural design model that served both patient audiences without requiring separate platforms.

From brief to reframed problem

The brief described a content problem. The real issue was a structural one that content alone couldn't solve.

Client brief

"Redesign the Verzenio DTC platform to better serve both early breast cancer and metastatic breast cancer patients — currently the experience isn't differentiated enough between the two audiences."

Reframed UX problem

The problem isn't insufficient differentiation — it's that both audiences are running through the same UX sequencing model. EBC and MBC patients don't just need different content; they need fundamentally different information architectures. EBC patients need emotion first — validation before evidence. MBC patients are further along their disease journey and need evidence first — clinical credibility before emotional support. Two sequencing models, not one with variations.

This reframe produced the EBC model (Emotion→Evidence→Action) and the MBC model (Evidence→Context→Support) as structurally distinct sequencing architectures served from one platform infrastructure.

UX approach

Two UX sequencing models were designed: EBC — Emotion→Evidence→Action; MBC — Evidence→Context→Support. I mapped the full patient experience ecosystem across both disease stages, identifying where UX could share infrastructure and where experience design needed to diverge.

Five UX design recommendations per audience across six content areas, with six MLR watch items sequenced for regulatory review alignment. MBC was identified as the source-of-truth UX navigation pattern, with EBC adapting the structural foundation to its distinct emotional sequencing requirements.

Key design decisions
Decision point Alternatives considered What we chose & why
Platform model — one site vs. two experiences
Two separate DTC platforms — one for EBC, one for MBC. Cleanest audience separation.
Single platform with distinct UX sequencing per audience. Two platforms doubled MLR overhead and maintenance cost; bifurcated sequencing was viable within one submission.
EBC sequencing — evidence-first vs. emotion-first
Lead EBC with clinical efficacy data — aligned with regulatory preference for clinical accuracy at the top of the hierarchy.
Emotion-first for EBC. Patients recently diagnosed with early breast cancer often don't identify as seriously ill. Leading with evidence before validating emotional experience created cognitive dissonance.
MLR watch items — batch vs. staged review
Submit all six MLR watch items simultaneously in standard batch review.
Staged sequencing ordered by UX dependency. Some watch items blocked downstream design decisions — clearing them first prevented late-stage redesign.
Navigation — shared vs. audience-branched
Shared global navigation across both audiences, content differentiated within pages.
MBC as source-of-truth nav; EBC adapted from it. MBC patients had more complex navigation needs — designing for complexity and simplifying for EBC produced better results than the reverse.
Research → insight → recommendation
Research input
Oncology DTC competitive audit + patient journey literature

Heuristic evaluation of breast cancer DTC platforms across CDK4/6 inhibitor competitors. AI-augmented structural pattern analysis. EBC vs. MBC disease-stage emotional differences and treatment decision-making research.

Key insight
All competitors used identical sequencing for both disease stages

Every platform audited applied a single IA across EBC and MBC — efficacy first, then mechanism, then support. No platform accounted for the fundamentally different information needs and emotional contexts between disease stages.

UX recommendation
Two sequencing models derived from disease-stage emotional arc research

EBC: validate the emotional reality of diagnosis before introducing clinical evidence. MBC: lead with clinical credibility — these patients have been through treatment and evaluate support against a high standard.

Transferable to

Multi-condition health platforms & chronic disease management apps. Designing structurally distinct experience flows for audiences at different disease stages applies to any health platform where user states differ meaningfully — diabetes management, mental health, and chronic condition apps often collapse these differences into one model, creating the same structural failure.

Figure 01 · Process Deliverable
MLR Alignment Process Map

MLR alignment process map — six-stage process showing how a dual-audience UX architecture (EBC and MBC) was brought through a single MLR review cycle. Each stage documents the friction point created by serving two opposing patient needs within one platform, and the UX decision that resolved it. Specific stakeholder roles not disclosed per NDA; process structure illustrative of methodology.

Figure 02 · UX Recommendations Deliverable
UX Optimization Recommendations — Page Architecture and Navigation

UX optimization recommendations — four page-level UX improvements delivered as a client-facing strategy document covering Savings & Support layout restructure, Side Effects tab architecture (Expect → Plan → Act), Patient Testimonial navigation elevation, and site-wide header optimization. Each recommendation presented as before/after schematic with UX rationale. Specific brand assets not disclosed per NDA; structure and methodology illustrative.

Figure 03 · UX Wireframe Comp
Side Effects Page — Tab Architecture Wireframe Comp

Side Effects page tab architecture — mid-fidelity wireframe comp showing the Expect → Plan → Act tab reveal structure across three states. Left: existing linear scroll layout with action content below fold. Centre: Expect tab active with annotation callouts. Right: Act tab active showing the immediate 24-hour action content surfaced within first viewport. Accordion format for side effects by treatment type shown in lower right. Client review deliverable prior to full asset development.

Figure 04 · UX Wireframe Comp
MBC Patient Stories — Navigation Restructure Wireframe

MBC Patient Stories navigation restructure — four-state wireframe showing the existing click path (3 levels deep through indication dropdown → About → Patient Stories) against the proposed primary navigation placement. Blue connector arrows trace the existing buried path. Proposed structure places Patient Stories between Common Questions and Savings & Support — one click from any page, reflecting the patient decision arc from clinical questions to peer validation to support enrollment.

Figure 05 · Deliverable
UX Alignment Framework

UX alignment framework — the primary UX strategy tool used to align clinical messaging, experience design priorities, and sequencing logic across two distinct patient audiences within a single DTC web experience. Five UX design recommendations per audience across six content areas, with six MLR watch items sequenced for regulatory review alignment.

Figure 06 · Deliverable
Mobile UX Recommendations

Mobile UX structural design recommendations — UX structural and navigation improvements across the Verzenio secondary pages for both EBC and MBC patient audiences. Core UX findings identified inconsistent labeling, hero visibility issues, and isolated layouts that increased page length without improving scannability.

Figure 07 · MLR-approved artifact
Produced Site Experience Design

MLR submission artifacts — fully produced Verzenio DTC platform delivered following MLR review and approval across both EBC and MBC indications, with distinct visual hierarchy and CTA design for each patient audience following the defined UX sequencing models.

Role
Experience design and UX architecture lead
Deliverables
MLR alignment process map, UX recommendations, wireframe comps, UX alignment framework, mobile audit, MLR-approved DTC site
Regulatory context
FDA · MLR
Industry
Pharmaceuticals · Oncology
If I ran this again

The dual-sequencing architecture was well-supported by the evidence. The one thing I'd shift: build the stakeholder case for structural divergence from the competitive audit outputs — before entering the design phase. When brand, clinical, and MLR teams can see that every competitor is running a single undifferentiated model, the argument for two sequencing architectures lands faster. I'd also bring more MBC patient voice into the evidence validation earlier; the disease-stage literature was strong, but lived experience data would have strengthened the MLR submission case for the Evidence→Context→Support sequence.